Table 2 Characteristics associated with 5-year transplant-free survival by Cox regression analysis in patients with primary sclerosing cholangitis

Sarcopenia via L3-SMI

5.561 (2.346–13.182)

< 0.001

2.749 (1.118–6.758)

0.028

Sex

0.607 (0.307–1.198)

0.150

Age

1.009 (0.988–1.032)

0.400

BMI

1.015 (0.982–1.048)

0.377

PSC-IBD

0.838 (0.451–1.559)

0.577

Liver cirrhosis

10.870 (4.714–25.070)

< 0.001

Malignancy

1.457 (0.736–2.883)

0.280

Dominant Stenosis

2.930 (1.359–6.317)

0.006

1.237 (0.516–2.961)

0.634

Ascites

6.528 (3.426–12.442)

< 0.001

Hepatic Encephalopathy

2.175 (1.074–4.405)

0.031

Splenomegaly

2.948 (1.581–5.498)

< 0.001

2.473 (1.203–5.087)

0.014

BMI reduction > 10% in 12

months

3.106 (1.636–5.894)

< 0.001

1.417 (0.703–2.856)

0.330

Recurring cholangitis (≥ 2x/6 months)

2.711 (1.424–5.161)

0.002

2.529 (1.190–5.376)

0.016

SEG

3.860 (2.122–7.021)

< 0.001

MELD score

1.121 (1.088–1.156)

< 0.001

Child-Pugh Grade

3.727 (2.302–6.036)

< 0.001

Mayo risk score

1.589 (1.325–1.905)

< 0.001

EASL 2022 CPG risk stratification

3.904 (1.396–10.919)

0.009

Platelets

0.997 (0.994–0.999)

0.015

Albumin

0.419 (0.307–0.571)

< 0.001

Bilirubin

1.114 (1.078–1.151)

< 0.001

1.079 (1.023–1.137)

0.005

INR

4.497 (2.720–7.435)

< 0.001

1.560 (0.673–3.617)

0.300

Creatinine

1.567 (1.018–2.411)

0.041

Sodium

0.894 (0.852–0.938)

< 0.001

Mode of cross-sectional imaging

0.342 (0.173–0.675)

0.002

SMI

0.973 (0.943–1.004)

0.083